Connect with us

Startups

Top 55 AI Startups in the US: Breaking $100M Milestones in Funding

Published

on

Palico, secondaries, LP-led secondaries

The AI Industry Trends in 2025: A Year of Growth and Innovation

The AI industry kicked off 2025 with remarkable momentum, setting the stage for a year of groundbreaking developments.

In 2024, a total of 49 startups secured funding rounds exceeding $100 million, as reported by TechCrunch. Among them, three companies achieved multiple “mega-rounds,” while seven companies raised rounds surpassing the $1 billion mark.

The pace did not slow down in 2025. While fewer companies secured rounds exceeding $1 billion, four, including Anthropic with two rounds over $1 billion, saw significant growth. Notably, eight companies raised multiple rounds compared to the previous year.

Looking ahead to 2026, early indicators suggest another robust year for the AI industry. Elon Musk’s xAI and Sam Altman’s Merge Labs made headlines with substantial funding rounds, hinting at continued growth and innovation.

The U.S. AI landscape witnessed several notable funding rounds in 2025:

November

  • Austin-based Mythic secured a $125 million venture round, led by DCVC, for its power-efficient AI compute solutions.

  • Chai Discovery raised $130 million in a Series B round, valuing the biotech AI model builder at $1.2 billion.

  • Fal announced a $140 million Series D round, led by Sequoia, propelling the generative media platform’s valuation over $4.5 billion.

  • Unconventional AI secured a staggering $475 million seed round, reimagining AI’s role in computing and reaching a valuation of nearly $4.5 billion.

  • Boston-based 7AI raised a $130 million Series A round for its cybersecurity AI agents, with Index Ventures leading the investment.

October

  • Fireworks AI, enabling AI application development with open-source models, secured a $250 million Series C round, valuing the company at $4 billion.

  • Enterprise AI startup Uniphore reached a valuation of $2.5 billion following a $260 million Series F round.

  • Sesame, specializing in voice AI, raised $250 million in a Series B round co-led by Sequoia and Spark Capital.

  • OpenEvidence in Cambridge raised $200 million in a Series C round for its AI chatbot in the medical field, valuing the company at $6 billion.

  • Lila Sciences announced a $350 million Series A round to develop a science superintelligence platform, co-led by Braidwell and Collective Global.

September

  • Periodic Labs secured a $300 million seed round for its AI scientist platform, with Felicis and Andreessen Horowitz leading the investment.

  • Cerebras Systems raised $1.1 billion in a Series G round for its AI infrastructure solutions, reaching a valuation of $8.1 billion.

  • Modular raised $250 million in funding, with US Innovative Technology Fund leading the round, highlighting the company’s innovative approach in AI infrastructure.

  • Distyl AI secured a $175 million Series B round, positioning the AI enterprise software company at a valuation of $1.8 billion.

  • Upscale AI raised $100 million in a seed round, emphasizing its role in AI infrastructure development and reaching a significant valuation.

  • Groq raised $750 million in a Series D-3 round for its AI inference solutions, valuing the company at nearly $6.9 billion.

  • Invisible Technologies achieved a $100 million fundraise, showcasing its impact in AI training and reaching a valuation of $2 billion.

  • Cognition AI raised $400 million in a Series C round, highlighting its vibe-coding capabilities and reaching a valuation of $10.2 billion.

  • Baseten raised $150 million in a Series D round, positioning the AI infrastructure startup at a valuation of $2.1 billion.

  • Sierra, a customer service AI agent platform, raised $350 million in a round led by Greenoaks Capital, showcasing its impact in the field and reaching a valuation of over $10 billion.

  • You.com, a personalized AI search engine, raised $100 million in a Series C round led by Cox Enterprises, positioning the company at a valuation of $1.5 billion.

  • Anthropic raised a $13 billion Series F round, showcasing its significant growth and valuation in the AI research landscape.

August

  • EliseAI raised $250 million in a Series E round, positioning the healthcare and housing automation platform at a valuation of $2.2 billion.

  • Decart secured $100 million at a valuation of $3.1 billion, underlining its impact in AI research and development.

July

  • Fal raised $125 million in a Series C round, led by Meritech Capital Partners, positioning the generative media platform at a valuation of $1.5 billion.

  • Ambience Healthcare raised $243 million in a Series C round, showcasing its role in AI healthcare solutions and reaching a significant valuation.

  • Reka AI secured $110 million in a funding round, highlighting its impact in AI research and development.

  • Thinking Machines Lab raised $2 billion in funding, positioning the AI research lab as a key player in the industry.

  • OpenEvidence in Cambridge raised $210 million at a valuation of $3.5 billion, showcasing its innovative AI-powered search tool for clinicians.

  • Harmonic raised $100 million in a Series B round, emphasizing its mathematical reasoning engine and significant valuation.

June

  • Abridge raised $300 million in a Series E round, positioning the healthcare AI unicorn at a valuation of $5.3 billion.

  • Harvey secured $300 million in a Series E round, showcasing its impact in AI tools for the legal industry.

  • Tennr raised $101 million in a Series C round, positioning the healthcare AI startup at a valuation of $605 million.

  • Glean announced a $150 million Series F round, highlighting its enterprise search solutions and significant valuation.

  • Anysphere raised $900 million in a Series C round, showcasing its innovative AI coding tool and reaching a valuation of nearly $10 billion.

May

  • Snorkel AI raised $100 million in a Series D round, positioning the AI data labeling startup at a valuation of $1.3 billion.

  • LMArena secured $100 million in a seed round, showcasing its community-driven benchmarking tool for AI models and significant valuation.

  • TensorWave in Las Vegas raised $100 million in a Series A round, highlighting its role in AI infrastructure solutions.

April

  • SandboxAQ closed a $450 million Series E round, positioning the AI model company at a valuation of $5.7 billion.

  • Runway raised $308 million in a Series D round, emphasizing its AI models for media production and significant valuation.

March

  • OpenAI secured a record-breaking $40 billion funding round, positioning the AI behemoth at a valuation of $300 billion.

  • Nexthop AI raised $110 million in a Series A round, highlighting its role in AI infrastructure development and innovation.

  • Insilico Medicine secured $110 million for its generative AI-powered drug discovery platform, reaching a valuation of $1 billion.

  • Celestial AI raised $250 million in a Series C round, showcasing its impact in AI infrastructure and reaching a significant valuation.

  • Lila Sciences raised $200 million in a seed round, emphasizing its science superintelligence platform and significant valuation.

  • Reflection.Ai secured $130 million in a Series A round, positioning the AI startup at a significant valuation.

  • Turing closed a Series E round, showcasing its impact in AI coding and partnerships with LLM companies.

  • Shield AI raised $240 million in a Series F round, positioning the AI defense tech startup at a significant valuation.

  • Anthropic raised $3.5 billion in a Series E round, highlighting its growth and valuation in the AI research landscape.

February

  • Together AI raised $305 million in a Series B round, emphasizing its role in generative AI and AI model development infrastructure.

  • Lambda secured $480 million in a Series D round, showcasing its impact in AI infrastructure solutions and significant valuation.

  • Abridge raised $250 million in a Series D round, highlighting its role in transcribing patient-clinician conversations and significant valuation.

  • Eudia secured $105 million in a Series A round, emphasizing its impact in AI legal tech and innovation.

  • EnCharge AI raised $100 million in a Series B round, showcasing its role in AI hardware solutions and significant valuation.

  • Harvey secured $300 million in a Series D round, emphasizing its impact in AI tools for the legal industry and significant valuation.

January

  • ElevenLabs raised $180 million in a Series C round, positioning the synthetic voice startup at a valuation of over $3 billion.

  • Hippocratic AI announced a $141 million Series B round, showcasing its role in large language models for the healthcare industry and significant valuation.

This article has been updated to reflect the latest developments in the AI industry as of January 19, 2026.

Techcrunch event

San Francisco
|
October 13-15, 2026

This article has been updated to remove that Abridge is based in Pittsburgh; the company was founded there.

See also  Breaking News: Oppo Reno 15 Unveiled with Impressive Specs and Sleek Design

Trending